This low-histamine pot roast recipe is seen as low histamine when compared to the traditional high-histamine version. For some, it may be beneficial to cook this pot roast in a pressure cooker to reduce histamine even more. When products are cooked for a longer period of time, histamine can build up.

What makes a traditional pot roast high in histamine is that it almost always contains ketchup, red wine, tomato-based broth, and occasionally malt vinegar or tomato paste. These ingredients are incredibly high in histamine and when combined, they will almost always overflow our histamine bucket. In this version, the allergen load is greatly reduced making it a low-histamine dinner recipe.